A PCR Blood Test Service for
Colorectal Cancer Screening
Most Common Cancer in Singapore
Colorectal cancer (CRC) affects any part of the colon and the rectum. It is the most prevalent cancer in males and the second-most prevalent in females in Singapore. (More)
Screening both detects cancers and helps to prevent them. Early detection of non-cancerous colorectal polyps and early-stage cancerous tumours allows their prompt removal. This increases the individual's chance of survival and quality of life. The Health Promotion Board (HPB) recommends screening once every 1 to 10 years, depending on the patient's risk for colorectal cancer. Screening is for all individuals 50 years old and above.
Why A Blood Test?
Blood tests have shown to increase colorectal cancer screening rates, which in Singapore remain low: the NUHS reported only 27.3% of individuals in the recommended age groups to have been screened for CRC by colonoscopy and/or stool tests. Alternative screening by blood increased colonoscopy confirmatory testing rates from 23% to 96% when patients are tested positive.
What is Epi proColon 2.0 CE?
Epi proColon 2.0 CE ("EPC") is intended for clinical use as a colorectal cancer screening blood test. It is an alternative to colonoscopy and stool screening tests (e.g., FIT, FOBT). It is not necessary to fast from food or medication prior to taking the EPC test.
What Does the EPC Test Detect?
Colorectal tumours naturally shed DNA from ruptured cells into the bloodstream. In >90% of CRC tumours, the Septin-9 gene is expressed in its methylated form. The Epi proColon 2.0 CE test detects this methylated Septin-9 DNA released into the blood with a test sensitivity of up to 95% and a specificity of up to 99%.
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